GABA: The Brain's Own Anti-Anxiety Medication

Feel Calm Without The Side Effects of Anxiety Drugs.

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Green Contains L-Theanine to Lower Anxiety - BenDad
Green Contains L-Theanine to Lower Anxiety - BenDad
Naturally decrease anxiety by elevating the brain's built-in Valium, GABA, with GABA-rich foods and with L-theanine, an amino acid found in green tea.

Anxiety has become nearly an epidemic today for thousands of people who chronically feel anxious, irritable and unfocused on a daily basis. And for some, chronic, untreated anxiety seriously interferes with their ability to function in social and workplace setting. Low levels of GABA, gamma-aminobutyric acid, may be a contributing factor because GABA deficiencies can negatively affect an individual's ability to manage even the most low level stressful situations.

GABA Deficiency Symptoms

A calming or "peacemaker" chemical in the brain, GABA induces relaxation, reduces stress and anxiety, and increases focus. One of the four key neurotransmitters, GABA also serves to keep all the other neurotransmitters in check. A deficiency can lead to:

  • Anxiety symptoms
  • Irritability
  • Headaches
  • Hypertension
  • Palpitations
  • Seizures
  • Lower sex drive
  • Disorders of the heart
  • Depression

Naturally Increase GABA:

While many people diagnosed with anxiety disorders take prescription medications such as Valium, Xanax or Ativan, benzodiazepine drugs that stimulate GABA receptors, these drugs often produce unwanted side effects and over time, can become less effective until the dose is increased.

Alternatively, individuals can gradually manage their mood disorder with a program that includes daily exercise, regularly eating foods that naturally elevate the production of key neurotransmitters and targeted supplementation.

Foods rich in complex carbohydrates increases GABA in the brain because they increases glutamine, an amino acid that is a precursor (needed in the formation of) to GABA. Introducing GABA-friendly foods into meals and avoiding excess simple sugars, white flours and wheat products (besides whole grains) can help elevate and maintain GABA levels.

Foods That Increase GABA:

According to Dr. Braverman, author of "The Edge Effect: Achieve Total Health and Longevity with the Balanced Brain Advantage," the following foods are high in glutamic acid/glutamate (forms glutamine, precursor to GABA):

  • Almonds, tree nuts
  • Bananas
  • Beef Liver
  • Broccoli
  • Brown Rice
  • Halibut
  • Lentils
  • Oats, whole grain
  • Oranges, citrus fruits
  • Rice bran
  • Spinach
  • Walnuts
  • Whole wheat, whole grains.

Supplement with L-theanine to Reduce Anxiety:

L-theanine, a naturally occurring amino acid found in green tea, raises GABA levels and has few if any side effects. L-theanine creates a calm feeling in people without the drowsiness many anti-anxiety medications have, and in almost a paradoxical affect, L-theanine also improves mental clarity and focus.

Suntheanine®, the tested and patented form of L-theanine, is produced by several vitamin companies and is available in most health food stores. Individuals should vary the dose and frequency according to their symptoms although most people find between 100 to 200mg one to four times a day is effective.

How GABA Works to Lower Anxiety

The brain emits four different kinds of brain waves which vary by frequency:

  1. Gamma waves seen in sound sleep
  2. Theta waves seen during sleeping or dozing
  3. Alpha waves which create a relaxed, awake state
  4. Beta waves which are present durng an awake, excited state.

GABA controls the brain’s rhythmic alpha waves, the normal brainwave in the encephalogram of a person who is awake but relaxed and drowsy. Alpha waves help the brain maintain physical and mental balance. Dr. Ray Sahelian, author of Mind Boosters explains, “GABA is the most important and widespread inhibitory neurotransmitter in the brain. Excitation in the brain must be balanced with inhibition. Too much excitation can lead to restlessness, irritability, insomnia, and even seizures. GABA is able to induce relaxation, analgesia, and sleep."

This key brain chemical is critically important to maintaining an overall sense of mental well-being. "GABA is also involved in the production of endorphins, brain chemicals that create a feeling of well-being known as ‘runners high.’," writes Dr. Braverman. "Endorphins are produced in the brain during physical movement, such as stretching or even sexual intercourse.” As endorphins are released people begin to feel a sense of calm, often referred to as the Endorphin Effect.

Although experiencing occasional anxiety is common, chronic anxiety can be debilitating and can dramatically decrease an individual's quality of life, as well as negatively impact their immune system.

Individuals suffering from chronic anxiety should ask their doctor to test their neurotransmitter and hormone levels because each has a complex relationship with the other that can affect numerous functions in the body, including mood regulation.

*Individuals should consult with their doctor before stopping any medication or combining supplements with medications.

Laura Owens, Andy

Laura Owens - Laura Owens has a B.S. in Psychology from Rollins College & U of FL. She is a freelance writer with expertise in motivation & wellness.

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117 Comments

Comments

Jun 2, 2009 11:45 AM
Guest :
Why not just use GABA supplements to directly increase levels of GABA?
Jun 5, 2009 11:34 AM
Laura Owens :
Hi,

GABA supplements do not necessarily cross the blood brain barrier, or if they do, not enough does. L-theanine does. See my article Do GABA supplements help anxiety? and my L-theanine (amino acid) articles.

Laura
Jul 2, 2009 7:13 AM
Guest :
I have tried the GABA supplements, and they give me a headache. Believe me, the food's MUCH easier to live with!
Jul 6, 2009 10:55 AM
Guest :
Hello, you recommend L-theanine but not L-Glutamin... the later apparently crosses the brain/blood barrier and then converts to GABA, whereas L-theanine potentiates the GABA effect. how do you comment on that?
Jul 6, 2009 4:18 PM
Laura Owens :
Good question. Glutamic acid, glutamine and GABA are a trio, all closely work together but are actually different.
My research shows some differences with glutamine and l-theanine. Glutamine converts to, L-theanine is used in "Formation of" gaba.
L-theanine, unlike Glutamine, has an anti-hypertensive affect(lowers blood pressure). They both have some slight differences in what they do in the brain/body. I also like that L-theanine is naturally occuring, it is "food based" in green tea. I suspect the body synthesizes it differently, although I'm guessing.
In addition, there appear to be more warnings with an overdose of glutamine, it converts to glutamic acid which unlike glutamine, is excitatory in the brain. L-theanine appears to be completely safe, with perhaps some drowsiness at the 300mg+ level.....
But Glutamine, while safe..has some warnings, "As a naturally occurring amino acid, Glutamine is thought to be a safe supplement when
taken at recommended dosages.However,people who have kidney disease,Reye's syndrome,cirrhosis of the liver,or other illnesses that cause ammonia to build up in the blood should not take Glutamine.For such individuals, taking supplemental Glutamine
may only cause further damage to the body. Those who are hypersensitive to monosodium glutamate should use L-Glutamine with caution, as the body metabolizes Glutamine into glutamate.If you are taking antiseizure medications use Glutamine only under medical supervision. Maximum safe dosages for young children, pregnant or
nursing women, or those with severe liver or kidney disease have not been fully determined.Be aware that although the names sound ‘similar’,Glutamine, Glutamic Acid,Glutamate,Glutathione,Gluten, and Monosodium Glutamate are all different substances.
http://www.naturalhealthweb.com/articles/esparza1.html
Jul 12, 2009 8:46 PM
Guest :
Laura what are your thoughts on Kava extract as a treatment for anxiety/nerves?
Jul 13, 2009 5:27 AM
Laura Owens :
I've tried Kava years back but I'm concerned about using any herb long term, short term fine. I also read of some potential damage to your liver. However, it IS effective for anxiety and in some cases, for certain forms of depression (according to a study out of Australia, University of Queensland, 2009). So yes it works, but I am reticent for anyone to take a long term herb/drug. While L-theanine might have a lower direct impact on reducing acute/high anxiety, I suspect when someone gets their GABA levels regulated with L-theanine, eating GABA foods, incorporating anxiety-reducing/GABA boosting behaviors into their life(breathing, yoga etc), their anxiety subsides.

In the short term I think Kava is great, particularly for acute anxiety. I DID notice when I tried it years back, a "hangover" affect, meaning I was extremely tired after it wore off, not sure if others have had the same reaction.
Jul 14, 2009 3:46 AM
Guest :
Hello,
I have a quick question. Is it a problem to take 2grams of Glutamine throughout the day and 750mg of Gaba at night before bed? Since these 2 are closely linked, do i need to be concerned? I do not have any medical conditions that warrant any sepcial attention.
Thanks you.
Doron
Jul 14, 2009 5:29 AM
Laura Owens :
Doron

I really don't know, but with such a gap in time, I would guess it's perfectly fine to take both. I found this Q & A that might help and then I have my own thoughts.....

http://www.vrp.com/deardoctorresults.aspx?ProdID=deard1283&zTYPE=3

I believe the key is if someone wants to supplement, there are key factors to consider:

- Will the supplements compete/interfere/interact with other supplements, medications or foods?

- What dose and timing of dose is sufficient to achieve desired results? I always suggest people take the LEAST amount of any supplement to get the desired result depending on what it is, then upping doses carefully. E.g. My 5-HTP I started slowly and upped as needed, ie. fish oil etc, I wasn't taking enough and I've doubled it.

- **Are you taking a brand that works, has been verified, tested for quality, USP stamping is helpful, but it's ALWAYS worth verifying a brand before dumping dollars into it. This is so underestimated. Often people dump hundreds of dollars into vitamins that do not absorb or break down properly. Then they conclude, xyz doesn't work, but in reality it was the BRAND that didn't work.

I love buying most of my vitamins online. I used I-herb.com, but have just switched to Swanson, great prices.

- Is GABA working? Some brands might claim to cross the blood-brain barrier, otherwise, I'd be skeptical about GABA, vs. L-theanine doing what's it's intended to do in the brain.

- Laura



Jul 24, 2009 7:41 PM
Guest :
I am taking L-theanine for my anxiety. I tried gaba until I found out that the hormones can cross in breast milk..BTW I am breast feeding... Gaba seemed to help my concentration better than L-theanine, is it me or is my mind tricking me? Also is it true that I cannot take Gaba while brestfeeding?
Jul 24, 2009 7:57 PM
Guest :
I am taking L-theanine for my anxiety. I tried gaba until I found out that the hormones can cross in breast milk..BTW I am breast feeding... Gaba seemed to help my concentration better than L-theanine, is it me or is my mind tricking me? Also is it true that I cannot take Gaba while brestfeeding?
Jul 26, 2009 4:30 PM
Guest :
I take both L-theanine and GABA. I have anxiety and depression. I found the day after starting GABA, I was much calmer. I didn't expect it to havea an effect like that. a few days later I started taking L-theanine. They've had such an impact that I can actually stop thinking in circles and slow myself down to see a diect problem. What is the benefit of taking these together?
Jul 29, 2009 12:50 AM
Guest :
Hello Laura, i have been suffering from chronic anxiety, depression and nausea for 2 years, it all started after a panic attack at work.
I have had a QEEG analysis done which showed that Delta, Theta and Alpha brain waves are signifficantly reduced and that Beta and High Beta are signifficantly increased.
I have also been found to be Testosterone defficient, and have severely delayed gastric emptying.
Some Drs i have seen think that these findings are unrelated but the Chiropractic neurologist who performed the QEEG believes they are all related to my disrupted brain waves.
I have been on just about every Anti Depressant there is but none of them have helped they don't even stop the depression let alone anything else, i also take 10mg of valium daily which doesn't really seem to stop the anxiety either, i also take 2000mg of fish oil and a magnesium supplement but that doen't seem to help either.
I am seriously considering taking GABA, L-Theanine or 5htp but my Psych Dr sais they are of no use because they cant cross the blood brain barrier, what would you consider a reasonable course of action for me to take, any advice would be good as these conditions have totally screwed my life.
Aug 7, 2009 2:08 PM
Laura Owens :
To the question about whether GABA crosses into breast milk....I really don't know but from what I've read GABA has not been tested in pregnant or lactating women. I'd have a holistic doctor answer this and would err on the side of caution.

To your second question, no, I don't think your mind is playing tricks on you, if it feels like GABA is working better than it IS simply because you believe it is (I'm a true believer of mind-body connection). L-theanine, however, has been shown to cross the blood-brain barrier, while GABA has not. Some company may produce a form of GABA that does cross the BBB but I don't know. I feel better about L-theanine given the safety aspects of it, it's an amino acid etc.
Aug 7, 2009 2:17 PM
Laura Owens :
Gaba or L-theanine? Take them both togethor?
I wanted to address this. I'm not a doctor or nutritionist; I'm a writer with a background in psychology. I do a tremendous amount of research on natural medicine.
The key is does GABA cross the blood brain barrier? According to this company, it can........I have no knowledge of this company or their products, but their info was interesting.....
http://www.good4all.net/bio2501.htm..to quote their website:
"The effects of BioSynergy’s GABA (Pharma GABA 80™) and L-theanine (Suntheanine™) are virtually identical however, studies indicate that Pharma GABA 80 is about 2.5 times more effective than L-theanine. So, if you have been taking BioSynergy L-theanine and are satisfied with the effects then you should continue. If you feel you need something stronger, you can try BioSynergy GABA. Both can be taken within the same day or even at the same time as there are no counteractive or adverse reactions between these two natural substances. Any feedback or comments if you have tried both would be appreciated by us and our customers."
Laura
Aug 14, 2009 6:48 PM
Guest :

to the person who on Jul 29, 2009 12:50 AM wrote that he (or she, I'll use "he") wrote that he suffers from panic attacks and valium 10mg doesnt help with anxiety. apart from trying theanine, gaba, valerien etc., you might want to try a beta blocker such as propranolol for physical controlk of panic attacks and not use valium but rather try alprazolam or clonazepam and see which works best. clonazepam has the advantage of being one of the least "addictive" benzos. beware though that anti-anxiety drugs can worsen depression.
Aug 24, 2009 9:21 AM
Guest :
My anxiety issues were caused by the drug cipro and include a beet red face, head rushes, and insomnia. Acupuncture helped a little I think. Now trying Gaba, and will add L-Theanine. It has been nearly two years and the symptoms sometimes seem worse than ever. I hope these supplements can combat the damage that the quinilone drug cipro did to me. Anyone out there with similar drug induced issues?
Aug 25, 2009 3:02 PM
Guest :
for a long time I have had strong anxiety problems probably be diagnosed bi-polar I have considered taking GABA.. I have not yet done this, however, I have been taking approx. 1 - 2 tablespoons of thyme daily and I really seems to help out greatly. Without GABA, thyme has had a history of about 5000 years of use whether it was medicene or used as part of a sacrifice( peace offering)thyme is used in toothpaste today(thymol)it is suppost to sanitize the mind. Health stores would be wise to carry the product since they carry other herbs.
Aug 25, 2009 3:06 PM
Guest :
for a long time I have had strong anxiety problems probably be diagnosed bi-polar I have considered taking GABA.. I have not yet done this, however, I have been taking approx. 1 - 2 tablespoons of thyme daily and I really seems to help out greatly. Without GABA, thyme has had a history of about 5000 years of use whether it was medicene or used as part of a sacrifice( peace offering)thyme is used in toothpaste today(thymol)it is suppost to sanitize the mind. Health stores would be wise to carry the product since they carry other herbs.
Aug 31, 2009 4:54 AM
Guest :
Hello,
I am 56 years young, blood type 0 which have high adrenalin, I don't do caffeine, chocolate and have to watch my sugar because of the stimulating affect. I seem to always be in high gear altho I don't have trouble sleeping for the most part. I do have occasions where I will wake up in the middle of the night trembling like I am cold and I my heart is jumping around...usually I get in a hot bubble bath and soak and relax and then am able to go back to sleep. This has always baffled me as to why I would wake up from a sleep in this state of anxiety?? Does anyone else experience this? My naturopathic physician suggested Kavinace...what is your feeling about this supplement? Will it make me too tired? For the most part I like my energy and don't want to feel lethargic I am just too busy most of the time. I have lost about 80 pounds and I do cardio 6 days a week....for my cardio I either take a brisk walk 4 laps around the park (approx and hour) or 30 min eliptical keeping my heartrate at 140 bpm...the long walk seems to calm the heart flutters better than the higher intense eliptical...any clues why this happens? Thank You! so much for your comments.
Teresa from Ohio
Sep 17, 2009 12:48 PM
Guest :
I have been diagnosed with GAD (8 years ago) and have been taking meds for a few years, however, as you know, there are always side effects. Currently I take Effexor XR (150 mg per day) but suffer from sleep interruption, low energy/motivation, night sweats, stomach upset and sexual side effects. I have dreams of getting off it. If I wanted to try GABA and L-theanine for my anxiety, how would I begin the process of switching from meds to these supplments? Is it likely that my doc would support this?
Sep 18, 2009 1:13 PM
Laura Owens :
Hi Teresa
Sorry for the delay. Since I'm not a physician I wouldn't dare diagnose but my suggestion is to get a thorough endocrine work-up from an Endocrine Specialist. Your primary can give you a referral or your OB/Gyn can.
How is your thyroid? How do your adrenals function? Some of the symptoms sound like panic disorder which is very treatable with lifestyle changes, behavior modification, and in some instances, meds. I've had that heart fluttering and panic at night before and I know it's from excesses, too much coffee, too much wine the night before, generally "too much."

As a whole, we are very hard on our adrenal glands in this society, work, lack of sleep, coffee, sugar, stress, few vacations, we burn them out all the time. Adrenal fatigue? thyroid? Panic disorder? Hope this helps. I'm not familiar with Kavinace, but I am familiar with Kava Kava if it's in that family. I'm not a huge Kava fan. I tried it years back for my fear of flying and found that it had a "crash" fatigue affect later. I know it can be used successfully for anxiety, but long term I don't recommend herbs unless you take a herb break, then it's fine.
Sep 25, 2009 10:00 AM
Guest :
My son has add. Very poor attention spand. was on adhd meds that didn't work. I have him on l-theanine. But i gave him 1 in the morning and one at night of 200 mg. so that is 400. Can I give him gaba on top of that? he is only 6 years old. what else can I give that would work better? l -theanine has helped in school but he still is having problems paying attention. email back momteam26@yahoo.com
Oct 11, 2009 1:21 AM
Guest :
Dear,Teresa from Ohio
I was getting heart palpations and took a magnesium and calcium supplement and it stopped.Maybe this could be you case? Doesn't hurt to try it?
Nov 9, 2009 1:30 AM
Guest :
Hi,
I've had the most hellish year for depression/anxiety/insomnia - not the first time I've experienced this but definately the worst episode. It began about 7 months ago and I hae tried everthing you can think of. Treatment for 'pyroluria', vitamin supplements of this and that, Proxan (which contains Same and 5-htp), 5-HTP alone etc. with little relief. I'd just about given up hope when I started looking into GABA deficiency and came across a Russian product called Picamilon - a combination of GABA and B3 - apparently the B3 helps it to cross the bllod brain barrier. I just had my first dose today - took a week to arrive - and I can feel the benefits already! The cloud has been lifted - hoorah!! You should give it a go too.. I ordered it through bodybuilding.com
Nov 9, 2009 7:51 AM
Laura Owens :
That's great that the GABA/B3 (niacin) combo worked for you. Everyone's brain chemistry is different and while one person might benefit from boosting their serotonin (mood, sleep related neurotransmitter), others might need to boost GABA (calming, alert, focus related transmitter, brains own "valium".)dopamine, acetylcholine etc. Likely many people have a combination of neurotransmitter deficiencies which is why I love Dr. Braverman's book, The Edge Effect. I posted on an article on that:http://naturalmedicine.suite101.com/article.cfm/prevent_anxiety_weight _gain_alzheimers_more. I suggest anyone interested in finding out if/what their neurotransmitter deficiencies,
contact NeuroSciences. It's an easy urine test. My doctor called to discuss the results, but the report is quite easy to interpret.
Dec 11, 2009 9:56 AM
Guest :
Laura,
I am soooo glad to have found your article. I am finishing a home based alcohol detox. I am an alcoholic of 5 hard years that got tired of not living. I have been extremely successful so far with my natural remedies vs conventional rehab. That being said, I have been researching studies that link insomnia in alcoholics with GABA deficiency. It appears without GABA the brain is unable to apply the brakes to the brain long enough to enter proper sleep cycles. This is explains the long bouts of racing thoughts i experience at all times of the night. I am in the last phase of my natural detox and struggled this week trying to figure the solution out.

What dosages would you suggest to someone needing substantial boosts to gaba? I have slept very little in the last 2 weeks because of the lack of alcohol to induce a relaxed state. Your input is most appreciated and I remove you from all liability from statements. Please speak to me with the understanding that I am a friend seeking advice and not holding you to it. Jason
Dec 14, 2009 4:33 PM
Laura Owens :
Jason

Congratulations for doing an alcohol detox. I hope you're under some kind of medical supervision as well. I'm not qualified to suggest dosing for L-theanine for an alcohol recovery program. I will say that I take 200mg a few times a day if I really need it. My doc said 3-4x a day is fine. I take it at night with my 3mg melatonin and my 5-Htp (precursor to serotonin) and magnesium, the combination is a wonderful sleep aid, not perfect, but very good. 5-Htp should NOT be taken with any MAOI or SSRI meds, and if taken, start with 50mg, and move up the dosing ladder as needed, 100, 150 etc. I take 200mg. L-theanine also helps with alcohol detox in the liver. Milk Thistle and Sam-e are very good liver support/de-tox supplements as well. All the best to you.

I think it's important to get your neurotransmitters tested at some point post-detox.... ZRT labs provides an at home urine test. Baseline levels are important to know if you are GABA, serotonin etc, deficient, and if so, how low. From that point, you can supplement and you can boost levels with nutrition and exercise (Dr. Braverman's book is very good, The Edge Effect)
Dec 17, 2009 5:08 PM
Guest :
For someone on Seroquel (25mg in the morning and 50 before bed) would you advise against taking a GABA supplement? Thank you.
Dec 19, 2009 7:33 AM
Laura Owens :
Regarding taking Seraquel with GABA: I could never suggest any combo of meds and supplements as I'm not a doctor. However, I would read this info on Seraquel first, and if your doctor suggests a GABA boosting supplement is safe, I'd take Suntheanine (L-theanine but the patened form Suntheanine) to elevate GABA levels, 2-3x a day or as needed, 200mg. GABA does not cross the blood brain barrier adequately. I cannot reccomend any supplements when someone is taking a med, particularly an anti-psychotic to treat bi-polar or schizrophrenia. I know people should NOT take MAOI's and SSRI boosting supplements if they are taking prescription meds, very dangerous. L-theanine is very, very safe, but again, do it in consult with your physician please. Seraquel: http://www.drugs.com/seroquel.html
Jan 22, 2010 6:12 AM
Guest :
Hey, do L-Theanine supplements contain caffeine? What about decaf tea and its Theanine content?
Jan 24, 2010 5:05 PM
Laura Owens :
RE: L-theanine....I do not believe L-theanine capsules contain green tea, but I'm not 100% sure. I'd suggest contacting this website to ask http://greentealovers.com/greenteahealthcatechin.htm#caffeine
as well as Taiyo International's website, they have the patent on the Suntheanine (reccomended form) of L-theanine and may be able to answer your question.
Jan 27, 2010 8:22 AM
Guest :
Is it safe to be taking Zoloft and begin taking a supplement of L-Theanine?
Jan 27, 2010 9:21 AM
Laura Owens :
Because I'm not a doctor, I have to disclaim, check with your doctor first. However, Zoloft is an SSRI antidepressant, and affects the re-uptake, or availability of serotonin. L-theanine on the otherhand, increases GABA in the brain and dopamine. From what I've read, L-theanine does not increase serotonin. I'd start slowly, and space out the dosing, don't take together, then gradually increase L-theanine. 200mg is ideal, a few times a day, according to your level of anxiety. Although taking an anti-anxiety supplement (admittedly a benign one) with an antidepressant med you might be canceling each out. It would help to get your neurotransmitters tested, ZRT labs, to measure your neuro levels.
Jan 31, 2010 7:12 PM
Guest :
I am on 6 x day Gaba + 2 L-Taurine. Do I need L-thyrosine?
Also does alcohool interferere with effectiveness of Gaba for anxiety?
Mar 11, 2010 8:13 AM
Guest :
I stopped taking SSRI's years ago and recently I started taking Twinlab GABAplus which includes niacinamide and inositol for some relief with the symptoms of CFIDS/FM. Not only do I feel that I have my life back from the depression, anxiety, and exhaustion of CFIDS, but GABA has reparied the sexual damage I suffered from the SSRI's. With the SSRI's I stopped having an orgasm during ejaculation. When I stopped taking them my orgasm did not return. Within 2 days of starting GABAplus my orgasm has returned better than ever. If there were such things as miracles, GABA would be it. I have heard all the stories about how it can't work because it can't cross the blood brain barrier, but there are just too many stories that it does work and I add my experience that it works better than anything else I have ever taken.
Mar 18, 2010 3:00 PM
Guest :

"My research shows some differences with glutamine and l-theanine"

Where are the peer reviewed publications from your research ?
Please send.
Yours. RLCOOP1@email.uky.edu
Apr 13, 2010 6:11 PM
Guest :
I thought this article was great had a friend tell me about GABA today because my wife struggles with Anxiety. I sure am glad this thing can help us out... I might even need some..

http://www.wordofpromise.info
Apr 19, 2010 4:37 PM
Guest :
@ RLCOOP1 - Where did she say her research included peer reviewed publications? Get off your high horse please, we all know they usually only study something when they can make huge proffits off it.

And for people asking medical advise, she has already stated numerous times she can't give medical advice, she isn't a doctor!

Thanks Laura for the article I have recently started taking GABA but will look into l-theanine next time.
Apr 27, 2010 9:27 PM
Guest :
I definitely live with Chronic Anxiety and have for about 6 years now. My doctor wants to put me on prozac and I just don't get it. There is a reason why I am feeling anxious, what is it. Yes, medication will help, but it is just masking the problem. Natural alternatives help to figure out what that actual problem is! I hope GABA helps, its worth a try, I use passion flower and 5 htp when needed.
Apr 29, 2010 11:36 AM
Guest :
I just got off Lexapro in dec. (after gaining 65 lbs in a year) and am still taking klonapin (.25mg as needed). I just went to an alternative medicine dr who has me on several suppliments to support stressed adrenals and help withthe chronic anxiety and depression I am dealing with. GABA was a suppliment he recommended for me but it is made with rice bean - an allergy of mine - so I can't take it. At the place where I buy my suppliments they recommended an amino-acid suppliment that contains:
vit c - 100mg
calcium - 100mg
vit b6 - 2mg
folic acid - 130mcg
magnesium - 50mg
zinc - 2mg
l-glutamine - 250mg
l-glycine - 100mg
l-taurine - 100mg
5htp - 20mg
d-phenylalinine - 10mg
Their claim is it helps your brain produce gaba naturally. Is this safe? Is this correct? Is it an ok alternative?

Thanks, Jennifer
Apr 29, 2010 5:54 PM
Laura Owens :
Hi Jennifer,

I'd love to say what the best regime is but I'm not a doctor or nutritionist, "just a writer" who does a fair amount of research on natural and holistic health, particularly natural mood balancing. My recommendation (and what I've done on my own) is to find a hormone/neuro balancing doctor (very often a former Ob/Gyn) who will check our neurotransmitters and hormones and CUSTOMIZE your regime based on your specific imbalances. Dr. Braverman's book the Edge Effect is a VERY helpful resource:

http://naturalmedicine.suite101.com/article.cfm/prevent_anxiety_weight_ga in_alzheimers_more

This supplement looks "good" but that is a relative term to what your body requires. I personally like l-theanine to boost gaba, but I have not taken GABA. I'm a HUGE fan of magnesium and read an entire book on that:

http://naturalmedicine.suite101.com/article.cfm/the_magnesium_miracle_bo ok_review

5 htp (I take that) is a wonderful precursor to serotonin, but how much is trial and error. Your formula has amino acids that are GABA and dopamine precursors.

The telling sign is how do you feel? track symptoms. More, get tested, get a baseline (ZRT labs) and work from there. Good luck!

-Laura

vit c - 100mg
calcium - 100mg
vit b6 - 2mg
folic acid - 130mcg
magnesium - 50mg
zinc - 2mg
l-glutamine - 250mg
l-glycine - 100mg
l-taurine - 100mg
5htp - 20mg
d-phenylalinine - 10mg

May 10, 2010 7:41 AM
Guest :
I am thinking about trying gaba for my anxiety/panic attacks.I am weening myself off tramadol and need something because my anxiety is so high...is it safe to take gaba with tramadol? Thank you
May 19, 2010 8:26 PM
Guest :
I LOVE IT!!! I have had hormone and brain transmitter imbalances for a long time, and I have been misdiagnosed and given several different Meds for MANY years.

The article states that foods rich in GABA are also the foods I do, in fact, "crave". Complex carbs (whole grains), dark chocolate, love almonds, walnuts, orange slices and also fish.

I intend telling my doctor about this article because I am ALSO a heart patient.

The issue of severe insomnia I could never, ever figure out why I could never, never fall asleep with prescription medications.

I am a victim, but you have given me a lot of hope for days to come.
May 20, 2010 4:55 AM
Laura Owens :
Thanks so much : ) So glad this article helped you. I wish more people were open to natural methods of balancing their brain and mood. It would change their life dramatically but it's hard for some people to shift their thinking into this world as we've grown up with trusting only traditional medicine. While any supplement needs to be used with caution (and checked against current medications for possible interactions etc.), there are numerous natural ways to get your brain back into balance. I still suffer with insomnia now and then but not often. Melatonin, magnesium, L-theanine (to boost gaba) calcium, all help. I happen to love Dr. Braverman's book, The Edge Effect, it's helped me a lot.
http://naturalmedicine.suite101.com/article.cfm/prevent_anxiety_weight_ga in_alzheimers_more
May 27, 2010 5:38 AM
Guest :
Hi,
I suffer from anxiety and insomnia I take zolpidem 10mg at night and dosulepin 50mg at night. I don't feel they do much. I've been reading about gaba and wondered if it could help me. Can I take with my medication. What would you suggest?
Jun 2, 2010 12:04 PM
Guest :
hi. im currently on a low dose of escitalopram for anxiety (6 mnths). but for the last 20 years i have had little sexual sensation and no orgasm at ejaculation.viagra etc helps with the ED but does nothing for the sensations. ive heard that gaba can help but is it ok to take alongside the escitalopram and my heart meds ( aspirin and statins). had heart attack 4 yrs ago.
Jun 2, 2010 1:13 PM
Laura Owens :
Because I'm not a doctor (I'm a writer) I can't suggest you combine certain supplements with your medication. What I did find on potential interactions I excerpted below. Also, I suggest L-theanine instead of GABA, an amino acid that stimulates the production of L-theanine. Some people have had success with GABA. I have not tried it because I had read that it does not readily cross the blood brain barrier.

**Essentially ANY medication that has a tranquilizing or blood pressure lowering affect could be amplified with GABA or L-theanine. Hope this helps. Laura

"Use extreme caution when combining GABA with other medications that have a tranquilizing effect, such as muscle relaxants, antidepressants, and alcohol. Do not operate heavy machinery until you are aware of how GABA affects your body.
* Blood pressure medication of any kind
* Stimulants, such as caffeine, amphetamines (including ADHD medications), and many street drugs.


L-Theanine Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when L-theanine is combined with any of the drugs listed above.

Blood Pressure Medications
Theoretically, combining L-theanine with a high blood pressure medication could increase the risk of low blood pressure (hypotension). Although this interaction could potentially be beneficial, it could also be dangerous (if blood pressure is lowered too much). Check with your healthcare provider before combining L-theanine with any blood pressure medicine. It may be especially important to monitor your blood pressure when starting or stopping L-theanine or a blood pressure medication.

Stimulants
Theoretically, L-theanine could make stimulant medications less effective. This is less of a concern for stimulants used for non-medicinal purposes.

oes not have any known drug interactions. However, you should always tell your healthcare provider about any other medications or supplements you are taking, including prescription drugs, nonprescription drugs, vitamins, and dietary or herbal supplements. Even though there are no known drug interactions with GABA at this time, it is important to understand that GABA supplementation has been studied very little in humans. It has certainly not been studied enough to rule out the possibility of interactions.
Jun 5, 2010 8:40 AM
Guest :
Hi Laura, I was wondering do you know if i take gaba supplements would it help stop my facial blushing/Flushing?
Ive been takin it for a week so far and it hasnt helped!
Does it take time to kick in or will this not help my problem at all?
How Much of gaba should i take to help my Problem?
Jun 22, 2010 9:46 AM
Guest :
Hello I am taking an anti-depressant and want to know if I should take L-Theanine with it. Pls assist me because my anxiety has made me have insomnia.
Francess
Jun 22, 2010 10:29 AM
Laura Owens :
Hi Frances,
Since I'm not a doctor I can't say absolutely, but L-theanine is a safe amino acid that increases GABA in the brain (the brain's calming, natural "valium" neurotransmitter. It has the amazing dual affect of calming the busy brain during the day but not making you drowsy, yet helping you fall asleep at night. I would recommend you take it, 200 mg 2-3x a day, yes, but again, the best bet is to talk to a doctor who offers holistic healing. I suggest anyone who suffers with mood challenges get their neurotransmitters tested (urine) and particularly with women, get their hormones tested (I suggest saliva) as well. A good baseline is key in deciding what to take, supplement, balance. Mood balancing specialists are available in many cities. I used a former Ob/Gyn who specialized in this area.
Jun 29, 2010 4:34 PM
Guest :
Hi Laura,
Do you think it is possible to become dependant on GABA or L-Theanine? I've heard that there may be a risk of anxiety becomming worse that it initially was if you stop taking them. Do you think this is true/a possibility?
Thanks Charlotte
Jun 30, 2010 11:14 AM
Laura Owens :
Hi Charlotte,

I haven't heard anything about the addictive potential of GABA or in particular, L-theanine (I don't research GABA supplements only L-theanine). According to the Suntheanine site, "Suntheanine can have noticeable benefits with doses as low as 50mg. However, for most adults, doses of 100mg to as much as 400mg or more are often used for greater effects. In doses of 400mg or greater, some people will experience some degree of sedation. This is advantageous if you are using Suntheanine to improve sleep quality, but it can be a problem during the day. Doses as high as 1000 mg of Suntheanine are safe but caution should be exercised if taking higher doses when you have to drive or operate machinery. "

Suntheanine is the patented form of L-theanine by Taiyo. It's the only form I take based on studies showing this patented form is more effective.
Jul 16, 2010 7:08 AM
Guest :
Laura, I am having trouble with side effects of an SSRI and trying w/o luck to adjust. I am getting headaches, nausea and blurred vision. Have Kava, GABA, 5HTP and St. John's Wort on hand. I don't know what to do. I want to go with a natural substance and I think anything that increases serotonin levels in me brings on the symptoms I mentioned (this would include 5HTP). I have mostly anxiety and some depression. Just don't know where to go from here. I am cutting a 10mg Lexapro into tiny slices and still am not able to function well until it practically wears off. Would like to have your suggestions, please.
Jul 16, 2010 7:17 AM
Guest :
Laura,
I am sensitive to monosodium glutamate(causes migraines). So does the L-Threanine increase glutamate? And would this be a possible side effect?
Jul 16, 2010 7:30 AM
Laura Owens :
Regarding L-theanine and glutamate sensitivity/migraines: MSG is a horrible, horrible substance, really a kind of poison that has been allowed to remain in foods for flavoring (and is listed as other things, not just MSG so it's disguised).

I don't think L-theanine increases glutamate, see my July 6th post, I think it will boost GABA directly. This is however, out of my scope of knowledge. I would suggest contacting Taiyo International directly (they patented the Suntheanine form of L-theanine and it's excellent, I only use brands that have Suntheanine, Now, Enzymatic therapy etc.). Ask your question and they can refer to their literature and their biochemists' knowledge. These chemical conversions are very complex, but as I understand it, L-theanine as an amino acid, would not be a problem for you. MSG sensitivity is quite common however, horrible stuff.
Jul 16, 2010 7:38 AM
Laura Owens :
Regarding side effects of SSRI's: Yes I understand, they can be nasty, or you habituate and have to boost the dose, for years. Many things can boost serotonin, I suggest 5-HTP, which is converted after trypotophan. 5-HTP is one step closer to creating serotonin in the chain of chemical events, though some folks like tryptophan better. St. John's is an herb and I like herbs with caution however, and I suspect you might have more drowsiness with that I tend to avoid herbs except for liver cleansing, that's just me. Kava Kava, not a fan, mostly due to the liver issues that have been associated with it, and I think it has a hang over effect. L-theanine is great for low key anxiety, mind racing, focus..it will boost GABA (the valium-like chemical in the brain). Stick with Suntheanine L-theanine only. BUT, my suggestion is always the same to folks battling moods, test test test THEN supplement. Get hormones tested (ZRT labs saliva) and neurotransmitters tested (urine), docs in town who specialize in mood balancing can do this, most mainstream docs don't do mood balancing. THEN work with the doc to supplement what YOU NEED, rather than a crapshoot, works miracles. Dr. Braverman's book the Edge Effect is a WONDERFUL resource to naturally mood balance and/or combine with traditional meds OR wean off. Best of luck, all moods can be balanced to give folks the life they deserve, guaranteed.
Jul 21, 2010 3:02 PM
Guest :

I've been taking .5mg of Xanax nightly for 3 weeks to sleep ( I have loud Tinnitus) I've read that Xanax can exacerbate my tinnitus problems and I woud like to stop it's use and start on something more natural I also have large cysts on both kidneys but am told no other kidney problems, Any suggestions ?
Jul 27, 2010 10:47 AM
Guest :
I bought some Suntheanine. Does it take some time for it to start working? Or should I expect results right away?
Jul 27, 2010 2:43 PM
Laura Owens :
It should work right away. I don't believe like anti-depressant medication, e.g. Zoloft or other SSRI's, this natural amino acid that increases GABA output in the brain needs time to "build up." Try taking 50-200mg, see how you do, it's a trial and error, as to how many times a day you need to up that dose. Likely 200mg is the best dosing each time. It ALL depends on how you feel, symptom improvement is key, feel better, stop, need more take more. It's an amino acid, quite safe.
Jul 30, 2010 7:10 PM
Guest :
Hi Laura,

I have spastic cerebral palsy and I've read that GABA can reduce spasticity by inhibiting muscle neurons. But I've also read that people with spastic CP do not absorb GABA properly to begin with, so I'm wondering if taking GABA supplements (or L-theanin) would benefit me or be of no use.
Aug 4, 2010 10:07 AM
Guest :
Ghb is a great form of gaba
Aug 24, 2010 4:34 PM
Guest :
I am concerned about the lack of information concerning how difficult it is to stop taking GABA. Is L thianine the answer? I know someone who is in agony because he has developed a tolerance to GABA and now he has insomnia and a raciing heart. Should theanine be traded out with GABA to get off GABA?
Aug 25, 2010 8:11 AM
Laura Owens :
RE: Addiction to GABA. I cannot speak directly to that for a couple of reasons. First is I don't research GABA supplements as I understand GABA has a harder time crossing the blood brain barrier and I question its safety. Second, my research and personal experience with L-theanine has been positive. L-theanine is a safe amino acid and it works for some but not others. Why? because every brain imbalance is different. I never, ever recommend (please note I'm not a doctor. I'm a writer although I do a tremendous amount of research) people try to come off any substance cold turkey. It's VERY important folks battling with mood imbalances, symptoms of neuro imbalances get their neurotransmitters and IMO, hormones tested. One size mood regulating regime does not fit all. L-theanine can help with insomnia. Racing heart at night? This could be a sign of a panic attack, cortisol or adrenaline levels escalating -- or a dozen other things. L-theanine BOOSTS GABA in the brain. GABA is an inhibitory brain chemical meaning it acts to quiet the brain, offer focus and calm, and can aid insomnia with "busy brain." Get tested, very important, get a baseline, work a regime from there. NEVER go cold turkey if an addiction is in place, dangerous.
Sep 7, 2010 2:12 AM
Guest :
does gaba make u grow?
Sep 17, 2010 9:19 AM
Guest :
Very informative article, thanks for the info!! I have a question, my son has had anxiety issues since he was very young; he is now a young adult & wants to try to go without prescriptions. Have you heard of Seredyn, a supplement with L-theanine, Valerian, Passion Flower, Niacinamide & Magnesium, if so what are your thoughts.
Sep 17, 2010 12:12 PM
Guest :
Interesting article. Your article mentions people with GABA deficiency get seizure. Could GABA supplement help lower frequency of seizures in epileptic patients? My son is epileptic. What test could show whether he is GABA deficient or not?
Sep 19, 2010 8:10 AM
Laura Owens :
Regarding Seredyn: I'm not familiar with that supplement but I like what's in it. All of the herbs, mineral magnesium and amino acid L-theanine are great. I suggest people use caution with herbs (which are wonderful) and read a bit more about Valerian and Passion Flower before taking every, single day. I'm a HUGE fan of magnesium and wrote a couple articles on mag. http://www.suite101.com/content/a-best-kept-secret-for-better-health-a58549
Sep 19, 2010 8:33 AM
Laura Owens :
As I'm not a doctor I can't say for sure, though I imagine anti-seizure drugs may have some GABA boosting response to them as GABA is a critically important brain/rhythm-balancing neurotransmitter. See this article: http://info.med.yale.edu/neurol/Richerson/Epilepsy.htm

You can test neurotransmitters via urine tests, one company that does that is: Pharmasan Labs, Neuroscience, although there are others as well. I'd also contact Dr. Eric Bravermen's practice (he wrote a book the Edge Effect about brain balancing being the key to all health). He recommends inositol and GABA supplements in his Brain Rhythm formula to treat seizures. Also, magnesium, B6, taurine, vitamin E, calcium.
Hope this help : )
Sep 26, 2010 12:41 PM
Guest :
What do you think about the medication Gabapentin? Does it increase Gaba in your brain as well? I have chronic pain and this is one of the meds I'm on as well as opiate meds.
Sep 26, 2010 10:48 PM
Guest :
for those wondering why not take gaba directly, the answer is: GABA does not cross the blood brain barrier at all (gaba dosnt get to your nerves directly), the brain has to make it, l-theanene helps your brain make GABA.
Oct 30, 2010 7:19 PM
Guest :
can GABA be given to a child who is having a fever to keep the fever down? especially if the child has history of seizure?
Oct 31, 2010 9:31 AM
Laura Owens :
RE: GABA and fevers. Hi, I don't believe GABA would do anything to reduce a fever since a fever is the body's sign of infection, a sign it's trying to fight off an illness. As such, in many regards a fever (if not too high) is a good thing. GABA on the other hand, is an inhibitory neurotransmitter and acts to increase alpha waves in the brain, so while I can see it helping seizures, I don't believe it would have any affect on fever reduction. - Laura
Nov 1, 2010 7:20 AM
Guest :
Laura,

Bless you! I've been tormented by tinnitus (noise in my ears) for over two years. After reading your article I figured I'd try taking small doses of l-theanine just to see if it does anything. Its been only three days and it has greatly reduced the tinnitus! Two years of struggling with this condition and now it seems like GABA deficiency played a role. I'm definitely going to look it this hormone deficiency and have that test taken that you recommend. I'm still in disbelief.... everybody told you can't just take a pill to cure tinnitus but wow what a difference this amino acid has made. I'm crossing my fingers it remains as effective.
Nov 1, 2010 12:18 PM
Laura Owens :
RE: tinnitus. I'm soo glad it's helping you. It's amazing how critically important a GABA balance is. This neurotransmitter is important in so many functions in the body. All the best to you in your recovery. : )
Nov 14, 2010 8:09 AM
Guest :
I've had seizures for many years and, again, I'm now feeling like I want to try somethng different. The medicine I take apparently works by increasing GABA in the brain.

I learned that regular GABA supplements don't really do anything. Does l-theanine definitely help increase GABA? If that can be my anti-convulsant, then it what I want to do.

I know you aren't a doctor, but I don't get much information from them; in my experience, they want me to continue with their prescription. However, I want an alternative.

- Brian
Nov 19, 2010 7:59 AM
Laura Owens :
Regarding GABA, L-theanine and seizures: Brian -

The answer is as far as I can tell, probably yes it would help. - Laura

L-theanine increases alpha waves and GABA and a GABA imbalance is involved in seizure activity in some individuals, see below. It's interesting but there is such a cascading affect with the brain's neurotransmitters. GABA is a key calming neuro, is involved in the regulation of serotonin and dopamine. When GABA is off, likely other neurotransmitters are as well.

http://www.web-us.com/l-theanine_anxiety_reducer.htm

"First, this amino acid directly stimulates the production of alpha brain waves, creating a state of deep relaxation and mental alertness similar to what is achieved through meditation.

"L-theanine is involved in the formation of the inhibitory neurotransmitter, gamma amino butyric acid (GABA). GABA influences the levels of two other neurotransmitters, dopamine and serotonin, producing the key relaxation effect. (2)"

2. Mason R. 200 mg of Zen; L-theanine boosts alpha waves, promotes alert relaxation. Alternative & Complementary Therapies 2001,April; 7:91-95

Study I found on Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/17725516, sifting through all the academic jargon, this stood out:

"we have provided direct evidence that seizures beget seizures and that GABA signaling plays a central role in this phenomenon. Indeed, recurrent seizures triggered in one hippocampus by a convulsive agent propagate to the other hippocampus and transform the naive hippocampus into one that generates seizures once disconnected from the other hippocampus."
Dec 11, 2010 10:36 AM
Guest :
Laura, I had a miscarriage, went into depression Dr. put me on zoloft only took 25mg for four days on day five took 50 mg that I was supposed to be taking,.had a bad reaction stopped taking it now I keep haveing severe panic attacks which I am taking atavan for. Is there a natural way to detox my brain, I think my hormones and the oversensitivity to zoloft is still in my system.
Dec 19, 2010 2:57 AM
Guest :
For those who think doctors have all the answers - you're wrong. Doctors usually know damn little about nutrition or herbs or how they interact when the pharm drugs that they sell. Doctors are a very poor source of information regarding nutrition across the board.
Dec 23, 2010 5:42 AM
Guest :
Awesome article and resources, thank you! I was diagnosed Bipolar II a couple years ago and was a rapid cycler. Abilify only doped me up so I wasn't being irrational but neither was I really "living." Went off that, got really bad, and found a doctor who put me on lithium. That made a huge difference. Then i started researching natural methods for Bipolar and found GABA on the list. I have been taking 750 mg of GABA (not every day but whenever I remember) along with an Omega 3-6-9 fish oil complex. I also try to take amino acids but haven't been taking them regularly. Was doing a lot of supplements including taurine and l-tyrosine etc. with the lithium now I just use GABA and the omegas. Honestly, it's turned my life around (along with healthier eating, sleeping more regularly, and a little more exericse...and I believe my relationship with God has made a big difference). Thanks for sharing this information; i intend to get a neurotransmitter baseline test done to see what else I might need to do for balance. All about doing it naturally!
Dec 26, 2010 2:04 PM
Laura Owens :
So glad the GABA is helping with your bipolar challenges. I so agree, the combination of exercise, aminos, mind/body/spirit, helps tremendously. I take L-theanine not GABA when I need it, because I read that GABA does not effectively cross the blood-brain barrier. However, many people have posted success using GABA supplements so perhaps certain formulas are effective.
Jan 11, 2011 7:37 PM
Guest :
I have epilepstic seizures, both tonic clonic (Grand Mal) and Simple Partial. I currently take Dilantin and Keppra. I'm currently using 750mg a day Gaba supplement to treat anxiety and trying to get some more focus. I've never been diagnosed with add or adhd and wouldn't take pharmaceuticals for it anyway. I am learning of new natural remedies. Would theanine be better than Gaba, and what would be the recommended dosages? Should I be concerned about taking either the Gaba or Theanine in combination with my current prescription meds? Thanks.
Jan 29, 2011 6:49 PM
Guest :
helpful. natural gaba stimulators need to be discussed and recommended. my wife is dying of valium/benzo addiction. i am looking for a way to help her out of a situation which has only one end.
Jan 30, 2011 4:13 PM
Guest :
Hello
I am a female at 40 years old and I am going through AA to treat an alcohol addiction I have had since I was 17. I have 5 days of sobriety today and am going to make the 90 meetings in 90 days - my life has become unbearable and my family is starting to suffer. I am taking 1 tsp of GABA a day - but would you suggest more? Or even less? Or should I take it at different times throughout the day? Thank you
Jan 30, 2011 4:37 PM
Guest :
Hello
I am a female at 40 years old and I am going through AA to treat an alcohol addiction I have had since I was 17. I have 5 days of sobriety today and am going to make the 90 meetings in 90 days - my life has become unbearable and my family is starting to suffer. I am taking 1 tsp of GABA a day - but would you suggest more? Or even less? Or should I take it at different times throughout the day? Thank you
Jan 30, 2011 5:46 PM
Guest :
Hello
I am a female at 40 years old and I am going through AA to treat an alcohol addiction I have had since I was 17. I have 5 days of sobriety today and am going to make the 90 meetings in 90 days - my life has become unbearable and my family is starting to suffer. I am taking 1 tsp of GABA a day - but would you suggest more? Or even less? Or should I take it at different times throughout the day? Thank you
Feb 12, 2011 5:20 AM
Guest :
i think the article was very interresting and right to the point very good and just what i need because i took the drug ativan and ruined my life and i would like to try it . please contact me sandragarcia531@comcast .net
Feb 20, 2011 4:23 PM
Guest :
I am a 28 year old female struggling with allergies, asthma, chronic sinus problems, ADD and anxiety (which seems to have erupted out of medications and lack of any form of relief). I have found no relief in the numerous doctor visits and the plethora of medication they have me on so I turned to more alternative medicines and accupuncture. I am trying to ween myself off of some of the medications I am on, in particular, the ADD medication and anxiety medication, in hopes that this will catalyze additional improvements in other problem areas and make my accupuncture more effective. I strive to eat a healthy diet, and exercise regularly. Would a GABA supplement be a reasonable option in this case? I understand you are not a doctor, but I am interested to know if you think this may be a viable option or if there are any other supplements you feel I should consider. Thank you.
-AB
Feb 21, 2011 4:56 PM
Guest :
I am a 28 year old female struggling with allergies, asthma, chronic sinus problems, ADD and anxiety (which seems to have erupted out of medications and lack of any form of relief). I have found no relief in the numerous doctor visits and the plethora of medication they have me on so I turned to more alternative medicines and accupuncture. I am trying to ween myself off of some of the medications I am on, in particular, the ADD medication and anxiety medication, in hopes that this will catalyze additional improvements in other problem areas and make my accupuncture more effective. I strive to eat a healthy diet, and exercise regularly. Would a GABA supplement be a reasonable option in this case? I understand you are not a doctor, but I am interested to know if you think this may be a viable option or if there are any other supplements you feel I should consider. Thank you.
-AB
Mar 11, 2011 12:34 PM
Guest :
Its a good informative article. Just to query some of the aspects. One is that GABA enhancer drugs are reported to cause decrease libido and cause erectile dysfunction, so the correlation of the GABA deficiency with low sex drive is not understandable. Regarding sleep apttern my personal experience is not good with GABApentine alone is not as good as compared with its combination with beta blocker drugs
Mar 11, 2011 12:40 PM
Guest :
Its a good informative article. Just to query some of the aspects. One is that GABA enhancer drugs are reported to cause decrease libido and cause erectile dysfunction, so the correlation of the GABA deficiency with low sex drive is not understandable. Regarding sleep apttern my personal experience is not good with GABApentine alone is not as good as compared with its combination with beta blocker drugs
Mar 15, 2011 11:44 PM
Guest :
For momteam26@yahoo concerning 2009 adhd post.
I am 26 years old and was diagnosed with add at 17. I tried a few of the pills they had out. Adderal was absolutely horrid. Lasted all of 3 days on that stuff and couldn't do it anymore. Concerta was an improvement I was still biting off my mom's head the 1st time she asked me to do something and then there was Stratterra the non stimulant. Better than all the rest. Still somewhat felt like myself. Learned how to concentrate better and got off of it because I didn't want to have to be stuck to taking pills everyday. Recently I've not only had to deal with the add but also with depression which seems to follow later on for those with add and adhd. I was at a point where I had to choose between being able to concentrate or being happy.I struggled with trying to do both through straterra and welbutrin. A chair or 2 across the room a couple of weeks later over something stupid made me come to understand that was not going to be possible. So I chose being happy. I am now taking just the welbutrin. By the way I'm probably one of the most self-controlled and easy-going laid back personalities you'd ever meet. Aggression issues are far from me. I typically take life as it comes and anyone who has known me since birth and just read that would be flabbergasted and honestly believe I was telling a tall tale. But I know the struggle you are having with your son because I've lived it from his shoes all my life which is why even though you posted over a year ago and knowing that you may never even come back to this site I wanted to respond to your post and let you know that there is still hope. I've tried L-theanine supplements too and they don't work half as well as GABA and VITAMIN B-COMPLEX supplements. I take 2 GABA in the morning and 1 B vitamin complex with B-3 in it along with my welbutrin. So you may just want to try 1 GABA with the B vitamin and see what works. I usually take 1 GABA at night along with a different type of B-vitamin for stress made by Enzymatic ( same people who make acidophilis pearls) it has more stuff in it for relaxation and can make you sleepy. It keeps my body stocked up on vitamin B though which acts as a catalyst for both the welbutrin and the GABA. All very important for working in the fast-paced and demanding world of retail. My concentration and productivity have quadrupled! Best of all I'm happy and I'm still me! Hopefully this will help you too. I'll be keeping you two in my prayers!
Mar 17, 2011 11:24 PM
Guest :
Excellent, well described for the average reader.
Mar 18, 2011 4:02 PM
Guest :
Hi Laura,
I read that you had a fear of flying? Well, I am an extreme case. I leave next week for a flight and I am already in deep anxiety over just a 2 1/2 hour flight.
What do you suggest for these situation related anxiety attacks. I'm so worried that I am considering taking a train.
PLEASE help. What do you suggest? Thank you.
Mar 20, 2011 5:37 PM
Guest :
I have been diagnosed with hypothyroidism in the last 5 months. I have take 500 mg of GABA daily for 7 months. Do you think there could be any relationship to my hypothyroidism by taking the GABA?
Thank you
David
Mar 26, 2011 5:52 PM
Guest :
Can GABA and Prozac be taken safely together?
Mar 28, 2011 3:42 PM
Laura Owens :
Hello,

To: Fear of Flying.

I'd suggest several things. Xanax really helps cut through extreme anxiety. While GABA and L-theanine supplements might help, I think for acute severe anxiety for a flight, I'd go with Xanax. More helpful long term however, would be to contact a specialist in phobias and engage in exposure therapy (very, very gradually exposes person to their fear), with biofeedback (learning to sense your anxiety and slow your breathing), cognitive therapy (recognize your thoughts and that these affect your reactions)......a combo of natural methods works, but for the upcoming trip, ask for a script for Xanax, only take when you fly. Anxiety and phobias, panic attacks, all of these can be overcome with a combination of therapies and natural anxiety relieving supplements...Some people reccommnd Emotional Freedom Technique (EFT) a tapping procedure, works wonders some believe for anxiety/panic. My belief system has helped me a tremendous amount (which I won't bore folks with here as it is spiritual/new age-ish)....as well as a glass of wine on flight, Xanax 30 minutes before flight, (but in truth you should not be combining Xanax with alcohol, but mine was a very, very low dose Xanax I got just for the flight, and one glass of wine. The combo of those and self-talking, deep breathing and my beliefs, did wonders : )) I was a happy flyer.
Apr 8, 2011 6:50 AM
Guest :
this article is realy an awsome piece of information....opened new way to think about the chemical present in our body....and the significant need of it.to our body....
May 4, 2011 10:36 AM
Guest :
Doesnt work....have tried. Klotopin works wonders for anxiety
Jun 5, 2011 3:43 PM
Guest :
Depression/anxiety is a common withdrawal symptom for people attempting to break an addiction. The overdoses of dopamine have caused D2 dopamine receptors in the brain to "shut off". The result is... the addict must either suffer low dopamine reception (thus depression/anxiety) or turn back to what ever addiction was stimulating the higher dopamine output. I am looking for a natural way to help the brain repair these receptors & balance brain chemestry. Have you found any research that would show that GABA or L-theanine might aid in this area?
Jul 20, 2011 10:07 PM
Guest :
Nice article, I know your not a fan of GABA supplements though I was wondering if 5htp could be combined with GABA for anxiety and depression from anxiety and fear
Jul 26, 2011 9:16 AM
Laura Owens :
Regarding combing 5 HTP supplements with GABA, yes absolutely, as long as you're not taking any medications that have serotonin or GABA affects. You'll likely need to experiment with the dosing on each. I find that the 5 HTP brands that have B6 etc, improve the effectiveness of the 5 HTP AND I recently found that the time-released (sustained release) work best for sleep, as they release through the night.

I really can't speak directly to whether GABA vs. L-theanine is right or wrong for someone because I"ve never tried GABA supplements. Many have posted here that GABA supplements are effective for them. I'd suggest the key is to go with GABA and L-theanine brands who are trusted, http://laura-owens.com/?page_id=2489 ideally, who are verified, although not all reputable supplement companies ARE verified, as the process is very expensive and can be cost prohibitive.
Aug 7, 2011 11:43 PM
Guest :
I've tried this anti anxiety/anti stress GABA tea, couldn't really tell if it worked or not, but it was good. I don't know if I'd order another package.
Aug 19, 2011 5:17 PM
Guest :
How can you test for neurotransmitters like serotonin and GABA in urine, if they cannot cross the blood-brain barrier?

Neuotransmitter testing just sounds like yet another money-making scheme, need to be careful these days.

On that note I did try L-Theanine a while ago, didn't really cut the mustard but I did notice a theraputic effect, it *changed* my anxiety, took the edge off, but made me feel quite irritated, I lowered my dosage to 50mg instead of 200mg and that reduced the irritation, but didn't eliminate it, I still feel my body is on alert, so it's no wonder cure.
Aug 23, 2011 11:35 AM
Guest :
hey...both of my sons have presentations for communication class. What do you suggest is the best thing to allow them to be at ease {no sweaty hands, no difficulties catching their breath as they present, no anxiety attacks} as they do their presentation.

We have currently elimianted all sugar, refined carbs, and caffeine
Taking Cod liver oil or Fish oil daily
B-complex vitamin daily
Calcium-Magnesium w/C daily

Suggestions?
Should they try that L-theanine / "Suntheanine"
or GABA or what are your suggestions to eliminate panic during speeches/talking in front of class,etc.
Aug 26, 2011 4:19 PM
Laura Owens :
RE: what to take before presentations, prevent anxiety attacks..... It's really hard to say because each person's underlying cause for anxiety, panic attacks is different. I suggest L-theanine (suntheanine) ONLY because GABA has been known to not always enter the blood brain barrier as well as L-theanine, yet many people have posted that GABA worked well. It depends entirely on the formula and the individuals issues/response. B's and fish oil are wonderful, as is magnesium as a co-factor for numerous functions, B's for nerves, Fish oil for mood, etc, all good. Mentally preparing for how to calm oneself, biofeedback exercises can be very effective to treat panic, anxiety. There are likely numerous websites around that address public speaking and anxiety in kids/adults.

Oct 1, 2011 4:19 AM
Guest :
Is it safe to take inositol , niacinamide along with l theanine? I have panic disorder with agorophobia, have been on paxil for years, now trying trying something else,, have been on inositol and niacinamide for afew days now--looking for something that works directly on gaba levels thank you-- Don
Nov 21, 2011 7:39 AM
Guest :
Is Gaba Supplumant ok to use on a 4 year old girl? if so what dosage?
Jan 23, 2012 4:11 AM
Guest :
I have some questions ;

1- is it suitable for speech for baby with 17 months & she has some autism's property?
2-is it based on megavitamin theory?
3- Did it contain vitamin b6 & C?
4- Did you have a local agent at Egypt?

Thanks in advance for your assistant & waiting your feedback
Feb 15, 2012 6:09 AM
Amy Ortiz :
HI Laura,
I have been on xanax for sleep because I had always been a light sleeper, and I cant not function well in the day if I dont rest at least 7-8 hours. Xanax from .25-.5 mg. Self medicated. I am trying to wean off of this. I think I do have a problem with the neuro transmitters cause at night I just cant seem to get into the "drift off to sleep" mode, unless I take the xanax. Or, I will be up at night plus I have acid reflux so I feel inside shaking at night - vibrations, etc.
I bought some gaba 750 mg and would need to know how to take it and also what do you sugguest about me taking the L-theanine and how much.
Ive taken valarian root, not much of a help, cause I cant drift off, Ive taken sleep md - helps somewhat, but I think im screwed up in the neuro. Please what is your opnion I know your not a doctor and with the right advise I know I can beat this.
Sincerely
Sleepless1
Feb 15, 2012 9:12 AM
Laura Owens :
Hi Amy,

Regarding sleep issues. I don't know the dosing on GABA but L-theanine is generally 200mg per dose. I suffered with some pretty extreme insomnia this year and since learned a tremendous amount about the sometimes hidden causes. I"m writing an e-book about it. Valerian will work like a sedative, but you really need to get the root CAUSE of your insomnia. Sleep anxiety (fear of not falling asleep, staying asleep) will contribute even after the physical symptoms are solved. Often hidden causes are anxiety, depression etc, but in my case it was adrenal fatigue which contributed to cortisol imbalance (too high or low will affect sleep), blood sugar (drops in blood sugar will wake you EVEN if you do not feel hungry), food allergy (I am gluten intolerant) will elevate histamine which is a stimulating neurotransmitter. Let me recommend you check out Integrative Pyschiatry's website. They work with people with sleep etc, issues, offer testing. You might in the meantime, want to try Kavinace (on their website), and/or Cortisol Calm (Enzymatic Therapy has a much cheaper version called Stressless Sleep), L-trytophan (1000mg +) or 5HTP, the latter two are precursors to the neuro serotonin. The key is to TEST.....the adrenal-neurotransmitter test, and/or their sleep test that measures key neuros that affect sleep. Call them and ask wht the reccomend for you. While expensive, getting tested will pinpoint your imbalance so you don't throw money at supplements that will not work; it's worth, in my opinion, the investment. The benzodiazepenes drugs, sleep aids are either highly addictive and/or have awful side effects/long term habituation. Good luck. I know what insomnia can do to your life and it CAN be cured, I promise.
Feb 15, 2012 4:59 PM
Amy Ortiz :
Hi Laura,
thank you for your response. The key to this is for me to get off the med. Underlying cause is stress, everyday stress, and yes, I fell the anxiety of not being able to fall asleep unless I take something. Its been a long time. But Im going to take the Suntheanine and the magnesium and 5 htp to see what happens tonite. Thank you I will see how this works and I would like to get tested. Thanks..
Feb 16, 2012 10:32 AM
Laura Owens :
Hi Amy,

I know how insomnia can make us desperate for sleep but I'd recommend starting with the magnesium and ONE of the neurotransmitter catalysts (suntheanine or 5HTP) at a time, then combining them both if need be. This way you can test (before you actually do a saliva test) what works best, GABA or serotonin catalysts. Some people find taking calcium-mag before bedtime but with a neuro and/or hormonal deficiency, this has to be addressed or the other more "mild" sleep aids (magnesium, calcium, melatonin) won't do the trick. 5 HTP converts to melatonin, btw.
Mar 23, 2012 4:35 PM
Guest :
Hello Laura!
My Name is Pablo
I suffer of constant dizziness for a while, my neurologist told could be stress related or migrane, i started taking effexor a week a go, i have a high anxiety right now, effexor sims to help but is causing stomach acidity and bladder pain, should i try Gaba?
thank you
Mar 24, 2012 7:45 AM
Laura Owens :
Hi Pablo,

Regarding migraines/anxiety and natural options instead of Effexor (which is a selective serotonin norepinephrine re-uptake inhibitor), it's hard to say unless you know the root cause of your migraines and anxiety. My advice is always the same, find a holistic doctor who can work with you to test your neurotransmitters. Integrative Psychiatry (online) has wide array of home testing products and a consultation available to interpret the results. There are so many underlying causes of migraines (70% of all "sinus" headaches are actually migraines my ENT doc told me)...... Magnesium for migraines may help..... I like Magnesium Calm (powder), ionic (liquid) forms taste awful but are very, very good. Anxiety - Suntheanine (l-theanine amino acid that converts to GABA in the brain) or GABA might help. I found something I use 3x a week for sleep called Kavinace and it's stronger than L-theanine/GABA, for high anxiety and/or sleep. It will make you drowsy. Don't take any supplements that increase your serotonin since you're already taking an SNRI, eg. 5HTP or tryptophan. Magnesium is a co-factor for serotonin but won't cause side effects. I'd try to wean off the Effexor given the side effects, GRADUALLY tapering your dose as you add Kavinace or GABA or Suntheanine.

But most importantly, get your neurotransmitters tested and interpreted, supplement from there, wean from Effexor slowly. Traditional docs will dismiss neuro testing as invalid but it's a good place to start so you at least have a baseline for what neuros (and hormones) may be off, serotonin? norepinehphrine? GABA? acethylcholine? etc.

And, don't dismiss that FOOD allergies can cause/exacerbate anxiety, creates histamines which is an excitatory neurotransmitter. Food allergies can affect mood dramatically.
Apr 23, 2012 11:57 AM
Guest :
Hi...I'm hoping you can help me too. My ND recently did a urine test on my neurotransmitters. My GABA is too high. Norepinephrine and Epinephrine are too low. serotonin is on the lowish end. How can I balance. She is going to have me try Glycine and a pill called Serenogin. I've had chronic insmnia for 7 months....at the end of my rope...
Apr 25, 2012 2:23 PM
Laura Owens :
Hi

RE: Low GABA, low epi, nor epi and insomnia (I too have been at the end of my rope with insomnia but with testing, targeted supplements, it's solved).

To elevate serotonin naturally 5 HTP or tryptophan at bedtime (30 minutes+ before).
I rotate them at night 100mg HTP or 1000-1500 of tryptophan.

You may want to get your adrenal glands tested. When our adrenals are functionally poorly due to exhaustion, stress (anything that taxes the adrenals to the point where they can no longer function properly), your HPA, hypothalimic-pituitary-adrenal axis may be off. I took the Adrenal Stress Index. Ask your ND about it. Have you had your cortisol tested? Your cortisol might be elevated at bedtime and in the wee hours (not normal). You might have food allergies which can create histamine (excitatory to the brain!). You might have low progesterone (another adrenal-related hormone). The adrenal feedback mechanism can be affected by several factors. Poor adrenal functioning can also affect blood sugar. If your blood sugar drops at night, your body will wake EVEN if you don't feel "hungry." Blood sugar control is important as well as neuro functioning. See if your adrenals are running properly then work with your ND from there.
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